Study: Cannabis May Suppress Epilepsy-Linked Genes

Published last month in the open-access journal PeerJ, investigators at the University of Reading say the findings strengthen support for chemicals in marijuana as seizure treatments.

“These results provide the first molecular confirmation of behaviorally observed effects of the non-psychoactive, anticonvulsant cannabinoid, CBDV, upon chemically (pentylenetetrazole)-induced seizures and serve to underscore its suitability for clinical development.”

Chemical structure of cannabidivarin.

CBD (cannabidiol) and CBDV (cannabidivarin) have both shown anti-seizure potential in animal studies, but human trials have so far only involved CBD.

Using rat models, the researchers found that CBDV could suppress not only seizure activity, but the expression of specific epilepsy-related genes as well.

The team focused on a set of genes that are significantly increased in epilepsy and are thought to contribute to the disorder.

Read more via Study: Cannabis May Suppress Epilepsy-Linked Genes – Leaf Science.

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